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PubMed: 18562203

Title
A possible link between astrocyte activation and tau nitration in Alzheimer's disease.
Journal
Neurobiology of disease
Volume
31
Issue
None
Pages
198-208
Date
2008-08-01
Authors
Berry R | Binder LI | Fu Y | Guillozet-Bongaarts AL | Horowitz PM | Reyes JF | Reynolds MR

Evidence beab905779
JSON

This antibody detects nitrated tau in soluble preparations from both severe AD brains (Braak stage V, VI) and age-matched controls, suggesting that nitration at Tyr 18 may be linked to astrocyte activation, an early event associated with amyloid plaque formation

act(a(BRCO:Astrocyte)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(BRCO:Astrocyte)) View Subject | View Object

Appears in Networks:

path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) View Subject | View Object

Appears in Networks:

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