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PubMed: 28176663

Title
GSK3β 5'-flanking DNA Methylation and Expression in Alzheimer's Disease Patients.
Journal
Current Alzheimer research
Volume
14
Issue
None
Pages
753-759
Date
2017-01-01
Authors
Cavallaro RA | Ciraci V | Ferrer I | Fuso A | Nicolia V | Scarpa S

Evidence da4b83615f
JSON

Here, we show for the first time that the administration of D-ribose, the most active glycator among monosaccharides, produces high levels of advanced glycation end products (AGEs) and, importantly, triggers hyperphosphorylation of Tau in the brain of C57BL/6 mouse and neuroblastoma N2a cells.

a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

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a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

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a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

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a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product") View Subject | View Object

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p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") View Subject | View Object

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p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") View Subject | View Object

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p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation a(CHEBI:"D-ribose") View Subject | View Object

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Evidence 4d7eb7d8a1
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We found that GSK3β mRNA was overexpressed only in patients with initial AD, with no effect on the levels of the protein. On the other hand, we unexpectedly observed the decrease of the inactive GSK3β in cortex from AD patients at Braak stages I-II, whereas considerable increase was observed in AD patients at stages V-VI compared to the control subjects.

a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

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Annotations
MeSH
Alzheimer Disease

a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 7d2ec5c9e9
JSON

Thus, our results suggest that Tau hyperphosphorylation was a result of ribosylated AGEs, rather than due to a direct reaction involving D-ribose.

a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

Appears in Networks:

a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:

a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.