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PubMed: 21427723

Title
The acetylation of tau inhibits its function and promotes pathological tau aggregation.
Journal
Nature communications
Volume
2
Issue
None
Pages
252
Date
2011-01-01
Authors
Cohen TJ | Guo JL | Hurtado DE | Kwong LK | Lee VM | Mills IP | Trojanowski JQ

Evidence 103bfa52ea
JSON

Although low-level tau acetylation was observed in untreated HEK-T40 cells, treatment with the pan histone deacetylase (HDAC) inhibitor trichostatin A (TSA), but not the Sir2 class inhibitor nicotinamide, resulted in a dramatic increase in acetylated tau levels.

a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) View Subject | View Object

Appears in Networks:

a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac)) View Subject | View Object

Appears in Networks:

act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac)) View Subject | View Object

Appears in Networks:

Evidence 276f0ebe3c
JSON

Thus, K280 acetylation is a feature found in a variety of human 4R or 3R/4R tauopathies including AD, but not 3R-tauopathies such as PiD.

p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration") View Subject | View Object

Appears in Networks:

path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.