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PubMed: 26390242

Title
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Journal
Nature medicine
Volume
21
Issue
None
Pages
1154-62
Date
2015-10-01
Authors
Wang C | Li Y | Chen X | Min SW | Gan L | Cong X | Defensor E | Ellerby L | Gestwicki J | Gibson BW | Johnson J | Krogan N | Masliah E | Minami SS | Mok SA | Schilling B | Shamloo M | Shirakawa K | Sohn PD | Tracy TE | Verdin E | Zhou Y

Evidence 092be89507
JSON

The acetyl-mimicking mutant K174Q slows tau turnover and induces cognitive deficits in vivo. Acetyltransferase p300-induced tau acetylation is inhibited by salsalate and salicylate, which enhance tau turnover and reduce tau levels. In the PS19 transgenic mouse model of FTD, administration of salsalate after disease onset inhibited p300 activity, lowered levels of total tau and tau acetylated at K174, rescued tau-induced memory deficits and prevented hippocampal atrophy.

a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) View Subject | View Object

Appears in Networks:

a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) View Subject | View Object

Appears in Networks:

a(CHEBI:salsalate) decreases p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus) View Subject | View Object

Appears in Networks:

a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

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