Title

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Volume

36

Issue

None

Pages

11283-11294

Date

2016-11-02

Authors

Allen ME | Bankston AN | Feng Y | Ku L | Li W | Liu G | Rui Y | Zheng JQ

p39, but not p35, is selectively upregulated by histone acetylation-mediated transcription, underlying the robust increase of Cdk5 activity during rat and mouse neuronal differentiation. Loss of p39 attenuates Cdk5 activity in neurons and preferentially affects phosphorylation of specific Cdk5 targets, leading to aberrant axonal growth and impaired dendritic spine and synapse formation.

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