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PubMed: 12578227

Title
Transglutaminase activity, protein, and mRNA expression are increased in progressive supranuclear palsy.
Journal
Journal of neuropathology and experimental neurology
Volume
62
Issue
None
Pages
173-84
Date
2003-02-01
Authors
Halverson RA | Kim SY | Lee JM | Muma NA | Troncoso JC | Zemaitaitis MO

Evidence d4b91be76b
JSON

Protein and mRNA levels of transglutaminase 1 were increased in globus pallidus of PSP as compared to controls. There were also significantly higher mRNA levels of the short form of transglutaminase 2 in globus pallidus of PSP (974% of control). Transglutaminase 1 mRNA and the long isoform of transglutaminase 2 mRNA (2212% of control) were significantly higher in PSP in the dentate of cerebellum. Together, these findings suggest that transglutaminase 1 and 2 enzymes may be involved in the formation and/or stabilization of neurofibrillary tangles in selectively vulnerable brain regions in PSP. These transglutaminases may be potential targets for therapeutic intervention.

a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) View Subject | View Object

Appears in Networks:

a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) View Subject | View Object

Appears in Networks:

p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus

path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus

path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)") View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus

path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dentate nucleus

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