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PubMed: 11738469

Title
Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease.
Journal
Neurochemistry international
Volume
40
Issue
None
Pages
17-30
Date
2002-01-01
Authors
Lee JM | Muma NA | Norlund MA | Singer SM | Zainelli GM

Evidence b5f80a1d06
JSON

The number of neurons that are immunoreactive with an antibody directed at the epsilon-(gamma-glutamyl)lysine bond was significantly higher in AD cortex compared with age-matched controls and schizophrenics. PHF tau-directed antibodies AT8, MC-1 and PHF-1 co-localized with epsilon(gamma-glutamyl)lysine immunolabeling in AD NFT. Immunoaffinity purification and immunoblotting experiments demonstrated that PHF tau contains epsilon(gamma-glutamyl)lysine bonds in parietal and frontal cortex in AD. In control cases with NFT present in the entorhinal cortex and hippocampus, indicative of Braak and Braak stage II, epsilon(gamma-glutamyl)lysine bonds were present in PHF tau in parietal and frontal cortex, despite the lack of microscopically detectable NFT or senile plaques in these cortical regions. The presence of PHF tau with epsilon(gamma-glutamyl)lysine bonds in brain regions devoid of NFT in stage II (but regions, which would be expected to contain NFT in stage III) suggests that these bonds occur early in the formation of NFT.

a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
frontal cortex
Uberon
parietal cortex
Disease Ontology (DO)
Alzheimer's disease

act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:
Annotations
Uberon
frontal cortex
Uberon
parietal cortex
Disease Ontology (DO)
Alzheimer's disease

act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Uberon
frontal cortex
Uberon
parietal cortex
Disease Ontology (DO)
Alzheimer's disease

path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
frontal cortex
Uberon
parietal cortex
Disease Ontology (DO)
Alzheimer's disease

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