Title

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.

Journal

Proceedings of the National Academy of Sciences of the United States of America

Volume

110

Issue

None

Pages

4604-9

Date

2013-03-19

Authors

Jin S | Wu J | Xiong Y | Xu Z | Zhang YQ | Zhao K

Overexpressed tau was hyperphosphorylated and resulted in decreased MT density and greater fragmentation. Using genetic screen, a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons. Genetic and pharmacological inhibition of the tubulin-specific deacetylase activity of HDAC6 indicates that the rescue effect may be mediated by increased MT acetylation.

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