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  3. PubMed:28771976

PubMed: 28771976

Title
HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease.
Journal
Aging cell
Volume
16
Issue
None
Pages
1073-1082
Date
2017-10-01
Authors
Jin J | Liu Y | Wang S | Xu Y | Ye X | Yu L | Zhu X

Evidence e3dbafe3a4
JSON

RGFP966, a selective HDAC3 inhibitor, has been shown to affect sensory cortical plasticity and memory formation (Bieszczad et al., 2015).

a(HBP:RGFP966) association bp(GO:memory) View Subject | View Object

Appears in Networks:

a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3)) View Subject | View Object

Appears in Networks:

bp(GO:memory) association a(HBP:RGFP966) View Subject | View Object

Appears in Networks:

Evidence 4ae5597a66
JSON

HDAC3 overexpression in the hippocampus increases Aß levels, activates microglia, and decreases dendritic spine density in 6-month-old APP/PS1 mice.

p(HGNC:HDAC3) decreases a(GO:"dendritic spine") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:HDAC3) increases act(a(CL:0000129)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.