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  3. PubMed:22253473

PubMed: 22253473

Title
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume
26
Issue
None
Pages
1946-59
Date
2012-05-01
Authors
Castillo-Carranza DL | Jackson GR | Kayed R | Lasagna-Reeves CA | Sarmiento J | Sengupta U | Troncoso J

Evidence ad3bf6076f
JSON

Phosphorylation at the epitope Ser202/Thr205 is regarded as a good marker for late-stage NFTs (5, 72). Hyman and colleagues (5) demonstrated that AT8 immunoreactivity is present primarily in eNFTs and in certain cases in iNFTs. These investigators also found that AT8 revealed dense neuropil thread staining.

a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 01af8614ba
JSON

This sequence (Fig. 3G–N) is supported by Western blot analysis, phosphorylated Thr231 in three AD cases and their age-matched controls, suggesting that tau phosphorylation at Thr231 occurs before the formation of oligomers (Fig. 3O).

p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

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