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PubMed: 29421605

Title
Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B.
Journal
Experimental gerontology
Volume
104
Issue
None
Pages
66-71
Date
2018-04-01
Authors
Botezelli JD | Cintra DE | Gaspar RC | Gomes RJ | Kuga GK | Leme JACA | Muñoz VR | Nakandakari SCBR | Pauli JR | Ropelle ER | da Silva ASR | de Moura LP

Evidence 77586948ce
JSON

Interestingly, the middle-aged rats have higher levels of PTP-1B, lower phosphorylation of IRS-1, Akt, GSK3β, mTOR, and TrkB. Also, the aging process increased Tau phosphorylation and β-amyloid content in the hippocampus region. In summary, this study provides new evidence that aging-related PTP1B increasing, contributing to insulin resistance and the onset of the AD.

bp(GO:aging) increases p(RGD:Ptpn1) View Subject | View Object

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p(RGD:Akt1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) View Subject | View Object

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p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) View Subject | View Object

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p(RGD:Irs1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) View Subject | View Object

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p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) View Subject | View Object

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p(RGD:Mtor, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) View Subject | View Object

Appears in Networks:

p(RGD:Ptpn1) negativeCorrelation p(RGD:Irs1, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(RGD:Ptpn1) negativeCorrelation p(RGD:Akt1, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(RGD:Ptpn1) negativeCorrelation p(RGD:Gsk3b, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(RGD:Ptpn1) negativeCorrelation p(RGD:Mtor, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(RGD:Ptpn1) negativeCorrelation p(RGD:Ntrk2, pmod(Ph)) View Subject | View Object

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