Title

Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease.

Journal

Molecular and cellular neurosciences

Volume

83

Issue

None

Pages

83-91

Date

2017-09-01

Authors

Bredesen DE | Rao RV | Theendakara V

Our results indicated a significant down-regulation of PPP2R5E gene expression and reduction in PP2A activity by ApoE4 compared with ApoE3. This may also explain an elevated Tau phosphorylation in AD human brains that featured at least one ApoE4 allele.

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