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PubMed: 19401603

Title
Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau.
Journal
The Journal of biological chemistry
Volume
284
Issue
None
Pages
16840-7
Date
2009-06-19
Authors
Asada A | Hasegawa M | Hisanaga S | Ishiguro K | Kimura T | Oikawa T | Saito T | Uchida C | Uchida T | Yotsumoto K

Evidence 20b194a187
JSON

Taken together, these results indicate that the binding of P-Tau to microtubules suppresses its dephosphorylation.

complex(GO:"tubulin complex") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) positiveCorrelation complex(GO:"tubulin complex") View Subject | View Object

Appears in Networks:

Evidence 2fb4ceb3bf
JSON

Pin1 is indicated to facilitate Tau dephosphorylation via PP2A by binding to the phospho-Thr-231-Pro or phospho-Thr-212-Pro site

act(p(HGNC:PIN1)) positiveCorrelation act(p(HGNC:PPP2CA)) View Subject | View Object

Appears in Networks:

act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) View Subject | View Object

Appears in Networks:

act(p(HGNC:PPP2CA)) positiveCorrelation act(p(HGNC:PIN1)) View Subject | View Object

Appears in Networks:

act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) View Subject | View Object

Appears in Networks:

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