Title

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

Journal

Biochimica et biophysica acta

Volume

1842

Issue

None

Pages

1527-38

Date

2014-09-01

Authors

Albrecht F | Arendt T | Arsalan-Werner A | Flach K | Goedert M | Herrmann L | Hilbrich I | Holzer M | Ramminger E

We show that axotrophin/MARCH7, a RING-variant domain containing protein with similarity to E3 ubiquitin ligases interacts with tau. We find here that tau becomes mono-ubiquitinated by recombinant tau-interacting RING-variant domain, which diminishes its microtubule-binding. Tau becomes mono-ubiquitinated by recombinant tau-interacting RING-variant domain reducing microtubule-binding.

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