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PubMed: 24853415

Title
Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function.
Journal
Cell death & disease
Volume
5
Issue
None
Pages
e1237
Date
2014-05-22
Authors
Chen CH | Hong Y | Kim BM | Kimchi A | Lee S | Lee TH | You MH | Zhou XZ

Evidence 135b66c8d5
JSON

DAPK1-mediated increase in tau protein expression and stability were accompanied by increased Pin1 Ser71 phosphorylation.

p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1) View Subject | View Object

Appears in Networks:

p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

Evidence 54a01b49ff
JSON

We showed previously that DAPK1 phosphorylates Ser71 in the catalytic active site of Pin1, thereby inhibiting its cellular function.

p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71)) View Subject | View Object

Appears in Networks:

p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1)) View Subject | View Object

Appears in Networks:

Evidence e4fb5ce583
JSON

As shown in Figure 7a, compared with the vector control, DAPK1, but not DAPK1K42A, increased the phosphorylation of exogenous tau protein in HeLa cells, as detected by Thr231-specific (AT180), Ser262-specific, and Ser396-specific (PHF-13) antibodies that recognize specific tau phosphoepitopes and/or abnormal conformations specific to AD NFT.

p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:

p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

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