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PubMed: 8702879

Title
Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions.
Journal
The Journal of biological chemistry
Volume
271
Issue
None
Pages
21108-13
Date
1996-08-30
Authors
Ishiguro K | Kusubata M | Matsubara M | Taniguchi H | Titani K | Uchida T

Evidence a7d04ca727
JSON

The phosphorylation sites were determined to be Ser551 and Ser553 with Cdk5-p23, and Ser62, Ser67, and Ser551 with MAP kinase. Upon phosphorylation with MAP kinase, synapsin I showed reduced F-actin bundling activity, while no significant effect on the interaction was observed with the protein phosphorylated with Cdk5-p23.

act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) View Subject | View Object

Appears in Networks:

act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553)) View Subject | View Object

Appears in Networks:

act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62)) View Subject | View Object

Appears in Networks:

act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67)) View Subject | View Object

Appears in Networks:

act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) View Subject | View Object

Appears in Networks:

act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551)) View Subject | View Object

Appears in Networks:

act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62)) View Subject | View Object

Appears in Networks:

act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67)) View Subject | View Object

Appears in Networks:

p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) View Subject | View Object

Appears in Networks:

p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) View Subject | View Object

Appears in Networks:

p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) View Subject | View Object

Appears in Networks:

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