PubMed: 24406748

Title
Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.
Journal
Neuroscience research
Volume
80
Issue
None
Pages
76-85
Date
2014-03-01
Authors
Hattori M | Horiguchi T | Iwashita H | Matsumoto Y | Nakamura K | Obayashi Y | Onishi T | Yano T

Evidence 770937dadc

We developed a transgenic mouse, named TPR50, harboring human P301S tau. Tau phosphorylation in the hippocampus of TPR50 mice increased with age, particularly at S202/T205. Therefore, cognitive dysfunction in TPR50 mice may result from early MT dysfunction and impaired axonal transport rather than accumulation of insoluble tau and neurodegeneration.

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