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PubMed: 20096481

Title
Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort.
Journal
Neurobiology of aging
Volume
32
Issue
None
Pages
550.e5-9
Date
2011-03-01
Authors
Berciano J | Bullido MJ | Combarros O | Frank A | Martínez-García A | Mateo I | Pozueta A | Rodríguez-Rodríguez E | Sánchez-Juan P | Valdivieso F | Vázquez-Higuera JL

Evidence be076ad3ea
JSON

Haplotype analysis of the block formed by rs2651206, rs10807287, and rs7764257 showed that the combination of the three frequent alleles (CTA) was significantly (p = 0.02) overrepresented in the AD group (67%) compared to the control group (63%), and this result was still significant after multiple testing corrections with 10,000 permutations (p = 0.05).

g(DBSNP:rs10807287) association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

g(DBSNP:rs10807287) association g(HGNC:TTBK1) View Subject | View Object

Appears in Networks:

g(DBSNP:rs2651206) association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

g(DBSNP:rs2651206) association g(HGNC:TTBK1) View Subject | View Object

Appears in Networks:

g(DBSNP:rs7764257) association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

g(DBSNP:rs7764257) association g(HGNC:TTBK1) View Subject | View Object

Appears in Networks:

g(HGNC:TTBK1) association g(DBSNP:rs2651206) View Subject | View Object

Appears in Networks:

g(HGNC:TTBK1) association g(DBSNP:rs10807287) View Subject | View Object

Appears in Networks:

g(HGNC:TTBK1) association g(DBSNP:rs7764257) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") association g(DBSNP:rs2651206) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") association g(DBSNP:rs10807287) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") association g(DBSNP:rs7764257) View Subject | View Object

Appears in Networks:

Evidence 5025241556
JSON

Activates cdk5 and GSK3; genetic variation protects against AD in Spanish cohort

p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.