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PubMed: 29281045

Title
Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease.
Journal
Journal of neuropathology and experimental neurology
Volume
77
Issue
None
Pages
139-148
Date
2018-02-01
Authors
Adler CH | Beach TG | Braithwaite SP | Lee KW | Mouradian MM | Oh S | Park HJ | Stock JB | Voronkov M | Yan R | Zhang J

Evidence 7b196faf87
JSON

Western blot analyses showed a decrease of methyl-PP2A and an increase of demethyl-PP2A with a concomitant reduction in the methyl/demethyl PP2A ratio in both PSP (74%) and AD (76%) brains, associated with an LCMT-1 decrease and a demethylating enzyme increase, protein phosphatase methylesterase (PME-1), in both diseases.

p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) View Subject | View Object

Appears in Networks:

p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(ECCODE:"3.1.1.89") View Subject | View Object

Appears in Networks:

path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) View Subject | View Object

Appears in Networks:

path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89") View Subject | View Object

Appears in Networks:

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