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PubMed: 9089387

Title
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.
Journal
Journal of biochemistry
Volume
121
Issue
None
Pages
179-88
Date
1997-02-01
Authors
Imahori K | Uchida T

Evidence b6fb9483e0
JSON

By using a yeast two hybrid system, TPKI was found to interact with pyruvate dehydrogenase (PDH), which is a key enzyme in the glycolytic pathway. PDH was phosphorylated in vitro by TPKI to reduce the activity converting pyruvate into acetyl-CoA, which is required for acetylcholine synthesis.

p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph))) View Subject | View Object

Appears in Networks:

act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph)) View Subject | View Object

Appears in Networks:

act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph)) View Subject | View Object

Appears in Networks:

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