Title

Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrP(Sc).

Journal

International journal of molecular medicine

Volume

30

Issue

None

Pages

569-78

Date

2012-09-01

Authors

Chen C | Dong XP | Gong HS | Guo Y | Liu Y | Shi Q | Tian C | Wang SB | Xie WL | Xu Y | Zhang BY | Zhang J

These finding highlight that treatment of PrP106-126 in cultured cells does not alter the level of total tau, but induces a reduction of p-tau262.

MARK4 was extremely decreased in the brain regions with a mass of PrPSc in a G114V gCJD patient, but was clearly observable in the regions with a minimum amount of PrPSc or without detectable PrPSc in a D178N FFI patient.

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