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PubMed: 23157676

Title
Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications.
Journal
Current molecular medicine
Volume
13
Issue
None
Pages
1098-109
Date
2013-08-01
Authors
Lu KP | Nakamura K | Zhou XZ

Evidence 6597dd7aaf
JSON

Pin1 accelerates cis to trans conversion to prevent accumulation of pathogenic cis p-tau conformation in AD, providing the first structural evidence for how Pin1 protects against AD.

p(HBP:"cis p-tau") negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates") View Subject | View Object

Appears in Networks:

act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau") View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"cis p-tau") View Subject | View Object

Appears in Networks:

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