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PubMed: 25974414

Title
Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms.
Journal
Scientific reports
Volume
5
Issue
None
Pages
9659
Date
2015-05-14
Authors
Buée L | Sergeant N | Buée-Scherrer V | Blum D | Hamdane M | Verdier Y | Vinh J | Derisbourg M | Carrier S | Chiappetta G | Demeyer D | Fernandez-Gomez FJ | Laurent C | Leghay C

Evidence c93e371b13
JSON

Hyperphosphorylation with Prostate-derived sterile 20-like kinase 1 alpha/beta (PSK1/TAOK2), Prostate-derived sterile 20-like kinase 2 (PSK2/TAOK1), CK1.

act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) View Subject | View Object

Appears in Networks:

act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) View Subject | View Object

Appears in Networks:

act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) View Subject | View Object

Appears in Networks:

Evidence 6d202b7bc5
JSON

While several N and C-terminally truncated Tau species are observed in AD brains, only a limited number of specific Tau cleavage sites, after residues Asp13, Asp25, Asn368, Glu391 and Asp421, have been identified so far in situ. The species generated by these cleavages are found in neurofibrillary tangles, and their occurrence is correlated with the severity of the disease.

p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*")) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*")) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*")) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

Evidence 8dbdc8d1a8
JSON

Regarding the effect of N-terminally truncated Tau, the Met11-Tau fragment showed the same properties as FL-Tau while Gln124-Tau was associated with a markedly increased level of acetylated tubulin compared to FL-Tau.

p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex

Evidence b43bb4737e
JSON

In agreement with this possibility, the investigation of another posttranslational modification of tubulin, detyrosination, which is also representative of a stable population of microtubules, revealed that it was significantly increased with Gln124-Tau when compared to FL-Tau

p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex

p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.