Title

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins.

Journal

The Biochemical journal

Volume

404

Issue

None

Pages

309-16

Date

2007-06-01

Authors

Dorval V | Fraser PE | Hay RT | Mathews PM | Mazzella MJ

SUMO3 overexpression significantly increased Abeta40 and Abeta42 secretion, which was accompanied by an increase in full-length APP and its C-terminal fragments. These effects of SUMO3 were independent of its covalent attachment or chain formation, as mutants lacking the motifs responsible for SUMO chain formation or SUMO conjugation led to similar changes in Abeta. SUMO3 overexpression also up-regulated the expression of the transmembrane protease BACE (beta-amyloid-cleaving enzyme), but failed to affect levels of several other unrelated proteins.

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