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PubMed: 21489990

Title
Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain.
Journal
The Journal of biological chemistry
Volume
286
Issue
None
Pages
20569-81
Date
2011-06-10
Authors
Han D | Li T | Lu Y | Paudel HK | Qureshi HY

Evidence 9650dfc876
JSON

In NGF-exposed PC12 cells, Egr-1 activates Cdk5 to promote phosphorylation of tau and inactivates PP1 via phosphorylation. Cdk5 phosphorylates Ser(396/404) directly. By phosphorylating and inactivating PP1, Cdk5 promotes tau phosphorylation at Ser(262) indirectly.

act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

p(RGD:Egr1) directlyIncreases act(p(RGD:Cdk5)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

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