Title

The microtubule-associated protein tau is phosphorylated by Syk.

Journal

Biochimica et biophysica acta

Volume

1783

Issue

None

Pages

188-92

Date

2008-02-01

Authors

Anderton BH | Derkinderen P | Geahlen RL | Hanger DP | Lardeux B | Lebouvier T | Reynolds CH | Scales TM

We report herein that Syk is also a tau kinase, phosphorylating tau in vitro and in CHO cells when both proteins are expressed exogenously. In CHO cells, we have also demonstrated by co-immunoprecipitation that Syk binds to tau. Finally, by site-directed mutagenesis substituting the tyrosine residues of tau with phenylalanine, we established that tyrosine 18 was the primary residue in tau phosphorylated by Syk.

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