Title

Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.

Journal

Journal of the American Chemical Society

Volume

133

Issue

None

Pages

15842-5

Date

2011-10-12

Authors

Bibow S | Biernat J | Blackledge M | Mandelkow E | Ozenne V | Zweckstetter M

The highly vulnerable CA1 pyramidal neurons were characterized by age- and disease-unrelated increases in PRCKB levels and by age- and disease-related increases in MAPK1 levels. In contrast, low PRKCB levels were found in CA2 pyramidal neurons, and MAPK1 levels were elevated in controls and intermediate AD stages. Both PRKCB and MAPK1 were increased in the late AD stages. MAPK1 and PRKCB levels were low in the brainstem and cerebellum.

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