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PubMed: 23407988

Title
Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology.
Journal
Acta neuropathologica
Volume
125
Issue
None
Pages
565-79
Date
2013-04-01
Authors
Hara M | Hirokawa K | Kamei S | Uchihara T

Evidence 0cfb2db5cb
JSON

The RD3+/4- (red) fraction was consistently higher in EC and CA1, which was serially followed by CA2, CA3, and CA4. This trend was reversed with the RD3-/4+ (green) fraction, which was consistently highest in CA4, which was serially followed by CA3, CA2, CA1, and EC.

a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

Evidence 221b4f5727
JSON

Dendritic arborization was abundant in RD3-/4+ pretangles, attenuated in RD3+/4+ neurons, and further attenuated in RD3+/4- ghost tangles.

a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:pretangles) increases complex(GO:"dendritic tree") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.