bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex"))

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PubMed:25652642

However in AD, exposure to high Aβ concentrations upregulates NF-κB activation increasing βAPP and Aβ processing, precipitating a feed-back loop that favor exacerbated Aβ production

Related Edges 5

• a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
• act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta")
• act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing")
• act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta")
• p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex"))

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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