a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")

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PubMed:19293145

Recent research interest has focused on the role of calcium dyshomeostasis in AD (Green and LaFerla, 2008); for instance, genetic links with the regulation of cytosolic calcium have been identified (Dreses- Werringloer et al., 2008). Thus nAChRs may provide a link between Abeta and disruption of calcium homeostasis.

Related Edges 5

• bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
• bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease")
• p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta")
• p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis")
• path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration")

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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