p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph))

PubMed:8282104

In conclusion, this cdc2-like kinase activity towards tau occurs in brain tissue and has an Mr of 31 kDa. These features are suggestive of other cdc2-like kinases cloned recently from brain, termed nclk [ 141, PSSARLE [28], or cdk5 [42,49]. Indeed, the 31 kDa protein reacted with an antibody specific for cdk5. Thus, the kinase isolated here is very similar if not identical to cdk5.

Confidence

High

MeSH

Brain

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.