act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1))

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PubMed:27795443

In this report, we describe a novel mechanism of action determined by the JunD component of AP-1, a factor enhancing cell survival in v-Src-transformed cells. We show that the loss of JunD results in the aberrant activation of a genetic program leading to cell death. This program requires the activation of the tumor suppressor death-associated protein kinase 1 (DAPK1). Since DAPK1 is phosphorylated and inhibited by v-Src, these results highlight the importance of this kinase and the multiple mechanisms controlled by v-Src to antagonize the tumor suppressor function of DAPK1.

Related Edges 3

• act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND))
• act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process")
• act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process")

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