a(CHEBI:"amyloid-beta") positiveCorrelation a(HBP:"Tau epitope, PHF1")

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PubMed:22156579

Consistent with previous reports (11,34), treatment of rat hippocampal neurons with synthetic Aβ, prepared using a well-characterized procedure that enriches for Aβ oligomers (37), resulted in increased tau phosphorylation at the 12E8 sites (Fig. 2A), suggesting that Aβ treatment had activated MARK kinases. Increased phosphorylation of tau at a site recognized by the PHF-1 phospho-tau antibody was also observed (data not shown).

Related Edges 2

• a(CHEBI:"amyloid-beta") increases p(HGNC:MARK4)
• a(HBP:"Tau epitope, PHF1") positiveCorrelation a(CHEBI:"amyloid-beta")

Uberon

hippocampal formation

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