a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates")

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PubMed:23528736

Trehalose, an natural disaccharide and mTOR-independent activator of autophagy (Sarkar et al., 2007), showed an effect on neuronal survival, reducing the level of tau aggregates in the brain of human tauopathy model mice (Kruger et al., 2011; Rodriguez-Navarro et al., 2010; Schaeffer et al., 2012).

Related Edges 2

• a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy)
• a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process")

MeSH

Brain

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