a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin))

PubMed:22102280

We report here that tideglusib inhibits GSK-3β irreversibly, as demonstrated by the lack of recovery in enzyme function after the unbound drug has been removed from the reaction medium and the fact that its dissociation rate constant is non-significantly different from zero.

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