p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4")

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PubMed:22908190

In this regard, elevated bCTF levels induced by APP overexpression, elevated dietary cholesterol, or overexpression of its receptor ApoE (particularly ApoE 14) can upregulate endocytosis and enlarge endosomes (Laifenfeld et al. 2007; Chen et al. 2010; Cossec et al. 2010), leading to impaired endosome retrograde transport (S Kim and RA Nixon, unpubl.).

Related Edges 14

• a(CHEBI:cholesterol) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
• a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis)
• a(CHEBI:cholesterol) increases a(GO:endosome)
• bp(GO:endocytosis) positiveCorrelation p(HGNC:APP)
• bp(GO:endocytosis) positiveCorrelation g(HBP:"APOE e4")
• bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol)
• p(HGNC:APP) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
• p(HGNC:APP) positiveCorrelation bp(GO:endocytosis)
• p(HGNC:APP) increases a(GO:endosome)
• g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
• g(HBP:"APOE e4") positiveCorrelation bp(GO:endocytosis)
• g(HBP:"APOE e4") increases a(GO:endosome)
• p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP)
• p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol)

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