a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:ERK))

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PubMed:29121589

Wild-type MEFs treated with DMF (20 μM) showed a time-dependent response effect activating phosphorylation of ERK (Fig. 2A, B) and p38 (Fig. 2A, C), that was maximal within 5 min. The Ser/Thr protein kinase AKT, an upstream regulator of GSK-3β, was also activated after 5 min as determined by increased phosphorylation of S473 (Fig. 2A, D)

Related Edges 4

• a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:p38))
• a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473))
• p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate")
• p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT))

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