act(p(HGNC:CTSD)) decreases path(HBP:neurotoxicity)

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PubMed:24027553

Cathepsin D seems particularly important for degrading tau, as its expression was neuroprotective in a Drosophila tauopathy model. Levels of cathepsin D are elevated in flies expressing mutant human tau. If cathepsin D is genetically ablated, these tau flies exhibit enhanced neurotoxicity and a shorter lifespan (93).

Related Edges 2

• act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT))
• act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection)

MeSH

Tauopathies

Text Location

Review

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