bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments")

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PubMed:7667312

Though whole tau assembled poorly, constructs containing three internal repeats (corresponding to the fetal tau isoform) formed PHFs reproducibly. This ability depended on intermolecular disulfide bridges formed by the single Cys-322. Blocking the SH group, mutating Cys for Ala, or keeping T in a reducing environment all inhibited assembly. On the other hand, Cys-322 can be oxidized, and this leads to PHF assembly (ref. 11; this report). In vitro this is achieved most easily by using constructs of the 'fetal' isoform of T (htau23) that has only three repeats. Conversely, reducing agents or the second repeat or T can be viewed as 'antidotes' against PHF assembly.The synthetic PHFs bound the dye thioflavin S used in Alzheimer disease diagnostics.

Related Edges 3

• a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments")
• a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S")
• p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments")

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