p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta")

PubMed:19293145

An indication that nAChRs may play a role in Abeta internalization comes from a close inspection of cholinergic neurons in brains from patients with AD, which revealed that neurons with high expression levels of alpha7 also contained large amounts of intracellular Abeta (Nagele et al., 2002). Addition of Abeta to the culture medium of neuroblastoma cells overexpressing alpha7 results in more Abeta internalization than in control cells with lower levels of alpha7 expression (Nagele et al., 2002).

MeSH

Brain

MeSH

Neurons

MeSH

Alzheimer Disease

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