composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph))

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PubMed:19293145

In neuroblastoma cells, as well as cultured hippocampal neurons, Abeta activates JNK and ERK, and blocking these prevents Abeta hyperphosphorylating tau protein, as does alpha7 antisense oligonucleotides or alpha7 antagonists, suggesting that Abeta may trigger tau protein phosphorylation through ERK and JNK via alpha7 receptors (Wang et al., 2003b). Abeta leads to phosphorylation of AKT in cultured mouse neurons through a mechanism that requires alpha7 nAChRs (Abbott et al., 2008), AKT phosphorylation levels returning to baseline upon prolonged application of Abeta.

Related Edges 4

• a(CHEBI:"amyloid-beta") increases act(p(FPLX:JNK))
• a(CHEBI:"amyloid-beta") increases act(p(FPLX:ERK))
• composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph))
• composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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