a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity")

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PubMed:21214928

Multiple lines of evidence demonstrate that overproduction of Abeta results in a neurodegenerative cascade leading to synaptic dysfunction, formation of intraneuronal fibrillary tangles and eventually neuron loss in affected areas of the brain [6,142]

Related Edges 3

• a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027)
• a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly")
• a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")

MeSH

Endosomes

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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