a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph))

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PubMed:10998059

Alsterpaullone, the most active paullone, was demonstrated to act by competing with ATP for binding to GSK-3beta. Alsterpaullone inhibits the phosphorylation of tau in vivo at sites which are typically phosphorylated by GSK-3beta in Alzheimer's disease. Alsterpaullone also inhibits the CDK5/p25-dependent phosphorylation of DARPP-32 in mouse striatum slices in vitro.

Related Edges 5

• a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin))
• a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin))
• a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
• act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph))

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