act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction")

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PubMed:25514383

Arora et al. (2013) investigated, in a cellular system, the effect of prolonged Abeta exposure on nAChR function. The rodent neuroblastoma cell line NG108-15 was transfected with alpha4beta2 nAChRs and treated for three days with 100 nM Abeta. The following acute stimulation with Abeta and nicotine led to receptor activation that caused a perturbation of intracellular calcium homeostasis followed by mitochondrial dysfunction and increased oxidative stress (Arora et al., 2013)

Related Edges 3

• act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis")
• act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress")
• composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR"))

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