act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph))

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PubMed:19293145

Shortterm nicotine application also induces phosphorylation of p44/42MAPK, p38MAPK, and STAT-3 and was mediated mostly by alpha7 nAChRs in rat vascular smooth muscle cells (Wada et al., 2007). It is noteworthy that the JAK-2/STAT-3 pathway also mediates the mitogenic effects of insulin, a process recently implicated in AD (Li and Ho¨lscher, 2007).

Related Edges 6

• act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph))
• act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph))
• composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS))
• act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease")
• act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine))
• path(MESH:"Alzheimer Disease") association act(p(HGNC:INS))

Cell Ontology (CL)

vascular associated smooth muscle cell

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