p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease")

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PubMed:27260836

Phosphatidylinositol binding clathrin assembly protein, PICALM (aka CALM) assembles adaptor protein-2 (AP-2) to clathrin, thus participating in clathrin-mediated endocytosis. We have previously reported that the level of full-length PICALM is decreased in AD brains; PICALM was co-localised with phosphorylated tau in NFTs and in granulovacuolar degenerations (GVDs) in the brains of AD patients and of individuals with Down syndrome but was not observed in amyloid plaques (Ando et al., 2013).

Related Edges 6

• bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits"))
• complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis")
• p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM)
• p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits"))
• p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph))
• path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM)

Disease Ontology (DO)

Alzheimer's disease

Disease Ontology (DO)

Down syndrome

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