path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4)

PubMed:19293145

Similar results have been obtained using subtype-specific antibodies. Binding of monoclonal antibodies raised against the alpha4 or the alpha7 subunit, for example, was significantly reduced in post mortem cortices of five patients with AD compared with five patients without AD of similar age (Burghaus et al., 2000). In one study, Western blots confirmed that the greatest reduction was in alpha4 (Guan et al., 2000). Likewise, subunit-specific antibodies reveal a reduced expression of alpha4 but not alpha3 or alpha7 in brains from patients with AD (Martin-Ruiz et al., 1999)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.