composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine))

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PubMed:19293145

Paradoxically, Abeta also activates the MAPK pathway through an alpha7-dependent pathway (Dineley et al., 2001; Bell et al., 2004). In human oral keratinocytes, the Ras/Raf/mitogen-activated protein kinase kinase 1/ERK pathway cooperates with the nicotine activation of the JAK/STAT-3 pathway (Arredondo et al., 2006); the Ras pathway induces STAT-3 upregulation whereas the JAK/STAT-3 pathway phosphorylates STAT-3.

Related Edges 4

• act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3))
• composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade")
• act(p(FPLX:RAS)) increases p(HGNC:STAT3)
• composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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