path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers")

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PubMed:19293145

Early work on AD considered the fibrillar form to be the toxic species. However, a lack of correlation between plaque burden and cognitive score contrasted with a strong positive correlation between total soluble amyloid and cognitive decline pointing to soluble, oligomeric forms as the primary toxic factor (Walsh and Selkoe, 2007).

Related Edges 3

• a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction")
• a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity)
• path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers")

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