a(CHEBI:heme) decreases bp(GO:"complement activation, classical pathway")

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PubMed:26875449

In contrast to its overactivating effects on the alternative pathway, heme inhibits the classical pathway. It binds to C1q, alters its electrostatic properties, and hampers the recognition of target molecules. This results in a reduction of classical pathway C3 convertase formation and C3b deposition.

Related Edges 2

• a(CHEBI:heme) increases bp(GO:"complement activation, alternative pathway")
• a(CHEBI:heme) decreases act(p(PFAM:C1q))

Cell Ontology (CL)

erythrocyte

MeSH

Serum

MeSH

Malaria

Text Location

Review

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